Serological identity between human alpha uterine protein and human progestagen-dependent endometrial protein

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Serological identity between human alpha uterine protein and human progestagen-dependent endometrial protein.

Alpha uterine protein and progestagen-dependent endometrial protein were previously described in human endometrium by two independent groups of workers. Serological evidence is presented in this paper that these two proteins are the same.

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Properties of the progestagen-dependent protein of the human endometrium.

Antigens A and B, shown to be associated with the progestagen-dominated human endometrium, were partly purified and their properties studied. The antigens were recovered in the crude nuclei, the heavy particulate fraction and cytosol of decidua-rich tissue from early pregnancy. The antigens in cytosol were enriched by a combination of Concanavalin A-Sepharose chromatography and polyacrylamide g...

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Functional characterization of the progestagen-associated endometrial protein gene in human melanoma

Utilizing gene microarray profiling of melanoma samples, we have recently identified a novel gene overexpressed in both thick primary and metastatic melanomas. This gene, progestagen-associated endometrial protein (PAEP), has never before been implicated in the oncogenic processes of melanoma, with its true function in oncogenesis and tumour progression relatively unknown. Overexpression of the...

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Human Malignant Melanoma-Derived Progestagen-Associated Endometrial Protein Immunosuppresses T Lymphocytes In Vitro

Progestagen-associated endometrial protein (PAEP) is a glycoprotein of the lipocalin family that acts as a negative regulator of T cell receptor-mediated activation. However, the function of tumor-derived PAEP on the human immune system in the tumor microenvironment is unknown. PAEP is highly expressed in intermediate and thick primary melanomas (Breslow's 2.5mm or greater) and metastatic melan...

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Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine activity would make it possible to propose more appropriate and effective management practices than those currently in use. Recent advances point to a role of the protein kinase C (PRKC) family in the regulation of u...

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ژورنال

عنوان ژورنال: Reproduction

سال: 1982

ISSN: 1470-1626,1741-7899

DOI: 10.1530/jrf.0.0650207